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Expression of the Circadian Clock Genes clock and period1 in Human Skin
Journal of Investigative Dermatology
The circadian clock is a cellular machine composed of proteins with regulated expression that gives rise to circadian rhythms. Two main new concepts have arisen from recent research in the ®eld in the last few years: (i) at least three to ®ve key genes are involved in maintaining the basic circadian cellular rhythms, and (ii) their expression is fairly ubiquitous, extending beyond the traditionally considered pacemaker in mammals, the suprachiasmatic nucleus. We have demonstrated the expressiondoi:10.1046/j.1523-1747.2000.00121.x pmid:10998156 fatcat:3rrr6ina3fbhxppdgaqiwchli4