Females undergoing laparoscopic gynecologic procedures are more vulnerable to get distressed by Post-operative Nausea and Vomiting (PONV). We conducted this study to evaluate the preoperative versus postoperative use of ondansetron, a commonly available, cost effective anti-emetic free of any side effects in the given dosage. Methods: This randomized, double-blind study was conducted on ASA grade I and II patients after assigning them randomly into groups A and B. Group A patients received 4mg

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... 2ml) Ondansetron as premedication before induction and 2ml normal saline at the end of surgery. Group B received 2ml normal saline as premedication before induction and 4mg (2ml) Ondansetron at the end of surgery. A standard anesthesia protocol was used in all the patients. They were assessed at regular intervals; 0-2 hours in PACU then at 2, 6, 8, 12 and 24 hours for the parameters, incidence of PONV (PONV score), number of patients requiring rescue antiemetic and time at which first rescue anti emetic was given, vitals and details of any side effects. Results: There was no incidence of PONV in group B against 8 % in group A. The rescue antiemetic requirement was 8 % in group A, with no requirement in group B. Both the groups were vitally stable intra and postoperatively. No clinically and statistically significant side effects were observed. Patient satisfaction was also good in group B (100 %) against 96 % in group A. Conclusion: Ondansetron 4mg intravenous effectively controls PONV with 100% patient satisfaction when given post-operatively compared to its preoperative use (96%). It can be highlighted for cost effectiveness and absence of any serious side effects in the dosage given.