HYPERTENSION ARTÉRIELLE ET EAUX MINÉRALES
and objective : It has been suggested that sensitivity of blood pressure (BP) to salt is related to other anions and cations besides sodium chloride. The objective of this study was to assess whether ingestion of sodium bicarbonate mineral water produced changes of BP levels and biochemical parameters in urine in patients with essential hypertension. Patients and methods : Pilot study in 132 adult hypertensive subjects who consumed 1.5 liters daily of mineral water with three different
... different concentrations of dry residue of 96.2, 183.2 and 1200 mg/L, respectively, during 9 weeks. BP levels and mineral urinary excretion were compared with baseline. Results : Systolic and diastolic BP decreased slightly in the three groups at 4 and 9 weeks: control water 8.6/7.8 mmHg, mild mineralization 1.14/2.39 mmHg, medium mineralization 2.7/0.96 mmHg (p=0.080). Results of regression analysis showed a negative association between BP increase and degree of mineralization since the water with the highest content in sodium chloride and sodium bicarbonate exerted a protective effect against BP increase at the end of the study (OR = 0.2 [95 % CI 0.1–0.6] ; p=0.008) compared with the control group. These effects were independent of initial BP and mineral urinary excretion concentrations. Conclusions : Consumption of sodium bicarbonate water with different mineral concentrations did not increase BP in adult hypertensive subjects. The inverse association between BP and water mineralization may indicate that ingestion of non-chloride sodium salts may protect against high BP.