Long-term Prognosis of Vascular Access in Haemodialysis Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study [post]

Fan-Yu Chen, Chun-Fan Chen, Ann Charis Tan, Chia-Hao Chan, Fu-An Chen, Wen-Sheng Liu, Tz-Heng Chen, Shuo-Ming Ou, Szu-Yuan Li, Ming-Tsun Tsai, Yung-Tai Chen, Chih-Ching Lin
2020 unpublished
Patients with systemic lupus erythematosus (SLE) have a higher risk of vascular complications. The objective of the study is to analyse the differences in the risk of arteriovenous fistula or graft (AVF/AVG) dysfunction in haemodialysis patients with and without SLE over a 10-year period. A final sample of 1366 SLE and 4098 non-SLE patients remained after propensity score matching. The outcome measure primarily evaluated is the incidence rate of AVF/AVG dysfunction. SLE patients had higher
more » ... ence rates of AVF/AVG dysfunction than non-SLE patients in all time periods. Three specific time periods that reached significant difference were the following: (1) after 1 year (incidence rates = 15.21, 13.01, respectively; subdistribution hazard ratio (SHR) = 1.15; P = 0.007), (2) 1st-to-10th-year period (incidence rates = 15.36 and 13.25, respectively; SHR = 1.16; P = 0.007), and (3) overall period (incidence rates = 23.53 and 21.66, respectively; SHR = 1.09; P = 0.027). In conclusion, there were significantly higher incidence rates of AVF/AVG dysfunction in SLE patients during the long-term follow-up period in this study.
doi:10.21203/rs.3.rs-111149/v1 fatcat:sgytr3mn7fhzziovunugn7mjmq