The art of war as applied to pediatric gliomas: Know your enemy
L'art de la guerre appliqué aux DIPG - Connais ton ennemi

Quentin Bailleul, Andria Rakotomalala, Isabelle Ferry, Pierre Leblond, Samuel Meignan, Alessandro Furlan
2021 M S.Médecine Sciences  
Pediatric brain cancers represent the most frequent solid tumors and the leading cause of cancer-driven mortality in children. Pediatric High Grade Gliomas display a very poor prognosis. Among these, DIPG (Diffuse Intrinsic Pontine Gliomas), localized to the brain stem, cannot benefit from a total exeresis due to this critical location and to their highly infiltrating nature. Radiotherapy remains the standard treatment against these tumors for almost five decades, and attempts to improve the
more » ... s to improve the prognosis of patients with chemotherapy or targeted therapies have failed. Thanks to the rise of high throughput sequencing, the knowledge of molecular alterations in pediatric gliomas strongly progressed and allowed to highlight distinct biomolecular entities and to establish more accurate diagnoses. In this review, we summarize this new information and the perspectives that it brings for clinical strategies.
doi:10.1051/medsci/2020279 pmid:33591259 fatcat:bdhlebipmzgd5lsokmqlohwvwy