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Separating distinct structures of multiple macromolecular assemblies from cryo-EM projections
2019
Journal of Structural Biology
Single particle analysis for structure determination in cryo-electron microscopy is traditionally applied to samples purified to near homogeneity as current reconstruction algorithms are not designed to handle heterogeneous mixtures of structures from many distinct macromolecular complexes. We extend on long established methods and demonstrate that relating two-dimensional projection images by their common lines in a graphical framework is sufficient for partitioning distinct protein and
doi:10.1016/j.jsb.2019.107416
pmid:31726096
pmcid:PMC6952565
fatcat:spg2sfvoxnb4nekr4dkdleve7e