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Key regulators control distinct transcriptional programmes in blood progenitor and mast cells
2014
EMBO Journal
Despite major advances in the generation of genome-wide binding maps, the mechanisms by which transcription factors (TFs) regulate cell type identity have remained largely obscure. Through comparative analysis of 10 key haematopoietic TFs in both mast cells and blood progenitors, we demonstrate that the largely cell type-specific binding profiles are not opportunistic, but instead contribute to cell type-specific transcriptional control, because (i) mathematical modelling of differential
doi:10.1002/embj.201386825
pmid:24760698
pmcid:PMC4168288
fatcat:rogqni2ntrfxxazhpjxkjn34xa