Membrane sorting via the extracellular matrix

Sina Sadeghi, Richard L.C. Vink
2015 Biochimica et Biophysica Acta - Biomembranes  
We consider the coupling between a membrane and the extracellular matrix. Computer simulations demonstrate that the latter coupling is able to sort lipids. It is assumed that membranes are elastic manifolds, and that this manifold is disrupted by the extracellular matrix. For a solid-supported membrane with an actin network on top, regions of positive curvature are induced below the actin fibers. A similar mechanism is conceivable by assuming that the proteins which connect the cytoskeleton to
more » ... he cytoskeleton to the membrane induce local membrane curvature. The regions of non-zero curvature exist irrespective of any phase transition the lipids themselves may undergo. For lipids that prefer certain curvature, the extracellular matrix thus provides a spatial template for the resulting lateral domain structure of the membrane.
doi:10.1016/j.bbamem.2014.10.035 pmid:25450353 fatcat:akw5olmqpjfb3hzymqgeiyszoy