Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein–protein interaction networks?

Santiago Schnell, Santo Fortunato, Sourav Roy
2007 Proteomics  
In protein-protein interaction (PPI) networks certain topological properties appear to be recurrent: network maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper, we investigate the role of protein disorder in the network topology. We find that the disorder of a protein (or of its neighbors) is independent of its number of PPIs. This result suggests that protein disorder does not play a role in the scale-free architecture of protein networks.
doi:10.1002/pmic.200600455 pmid:17285562 fatcat:ezeofyhi7negpdebvp7hmuxrhq