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Computer-aided systems for skin lesion diagnosis is a growing area of research. Recently, researchers have shown an increasing interest in developing computer-aided diagnosis systems. This paper aims to review, synthesize and evaluate the quality of evidence for the diagnostic accuracy of computer-aided systems. This study discusses the papers published in the last five years in ScienceDirect, IEEE, and SpringerLink databases. It includes 53 articles using traditional machine learning methodsdoi:10.3390/diagnostics11081390 fatcat:r4gyqfwberfofhcbx2xsn7vpf4