The antimicrobial activity of a methanol extract of Mitracarpus verticillatus was evaluated against some bacteria and dermatophytes. The Mitracarpus verticillatus methanol extract possesses both antibacterial and antifungal activities. This extract was subsequently fractioned and the three different fractions were screened for antibacterial activity and secondary metabolites. Methanol extract residue displayed a higher degree of antibacterial activity, than the other two fractions

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... ne soluble fraction and ethyl acetate soluble fraction). The fractions were all positive for alkaloids, glycosides, steroids, and cardiac glycosides. Methanol extract residue showed the presence of tannins, saponins, flavonoids and phlobatannins; while anthraquinones and terpenes were detected in the other two fractions. A compound was isolated via thin layer chromatographic method from the methanol extract residue. The ultraviolet and visible spectrophotometric and infrared spectroscopic studies of this isolated compound suggest it to be flavonol.