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Regulation of protein–protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes
2013
Molecular Biosystems
Phosphorylation offers a dynamic way to regulate protein activity, subcellular localization, and stability. The majority of signaling pathways involve an extensive set of protein-protein interactions, and phosphorylation is widely used to regulate protein-protein binding by affecting the stability, kinetics and specificity of interactions. Previously it was found that phosphorylation sites tend to be located on protein-protein binding interfaces and may orthosterically modulate the strength of
doi:10.1039/c3mb25514j
pmid:23364837
pmcid:PMC3665713
fatcat:t3ogrk3k7vepfo7jxcctxr4vom