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Firing Mode-Dependent Synaptic Plasticity in Rat Neocortical Pyramidal Neurons
Journal of Neuroscience
Pyramidal cells in the mammalian neocortex can emit action potentials either as series of individual spikes or as distinct clusters of high-frequency bursts. However, why two different firing modes exist is largely unknown. In this study, we report that in layer V pyramidal cells of the rat somatosensory cortex, in vitro associations of EPSPs with spike bursts delayed by ϩ10 msec led to long-term synaptic depression (LTD), whereas pairings with individual action potentials at the same delaydoi:10.1523/jneurosci.0795-04.2004 pmid:15163685 fatcat:y6bjwpnwj5drblzr4wejpby2bi