PREPARATION AND CHARACTERIZATION OF ALGINATE AND CHITOSAN IPC BASED GEL FORMULATION FOR MUCOSAL APPLICATION

SEDA RENÇBER, Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 35100, Izmir, Turkey, CATALINA NATALIA CHEABURU-YILMAZ, FADIME AYDIN KÖSE, SINEM YAPRAK KARAVANA, ONUR YILMAZ, "Petru Poni" Institute of Macromolecular Chemistry, 700487, Iasi, Romania, Ege University, Faculty of Pharmacy, Department of Biochemistry, 35100, Izmir, Turkey, Ege University, Faculty of Pharmacy, 35100, Izmir, Turkey, Ege University, Faculty of Engineering, Leather Engineering Department, 35100 Bornova, Izmir, Turkey
2019 Cellulose Chemistry and Technology  
Interpolymeric complexes (IPCs) have the advantage of combined properties of their constituent polymers. They are easy to prepare under mild conditions and do not require high processing costs. The interpolymeric complexes of alginate, chitosan and Nystatin, as antifungal drug systems, represent an alternative for mucosal illness treatment. The composition of the two polymers is a key parameter in obtaining the desired properties for pharmaceutical formulations. IPCs of sodium alginate (SA) and
more » ... m alginate (SA) and chitosan (CS) were prepared via solution mixing method with various compositions, followed by coacervation in 2-propanol. The outcome obtained from rheological measurements was that the complex SA/CS 60/40 (v/v %) fulfilled the requirements of a semi-solid formulation, e.g. pseudoplasticity. Nystatin showed very good compatibility with the polymeric system. The drug loaded gels showed better rheological, textural and mechanical properties (e.g. pseudoelasticity, spreadability, surface adhesion etc.). The final gel formulations showed no cytotoxic effects in the cell culture assay.
doi:10.35812/cellulosechemtechnol.2019.53.64 fatcat:fb54rhz2rncupfkponfu3fefce