IMGT®, the international ImMunoGeneTics information system® 25 years on

Marie-Paule Lefranc, Véronique Giudicelli, Patrice Duroux, Joumana Jabado-Michaloud, Géraldine Folch, Safa Aouinti, Emilie Carillon, Hugo Duvergey, Amélie Houles, Typhaine Paysan-Lafosse, Saida Hadi-Saljoqi, Souphatta Sasorith (+2 others)
2014 Nucleic Acids Research  
IMGT R , the international ImMunoGeneTics information system R (http://www.imgt.org) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT R marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT R is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF
more » ... nd MhSF superfamilies. IMGT R is built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and 3D structures. The concepts include the IMGT R standardized keywords (identification), IMGT R standardized labels (description), IMGT R standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT R comprises 7 databases, 17 online tools and 15 000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data. Tools and databases are used in basic, veterinary and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunologi-cal applications (FPIA). IMGT R is freely available at http://www.imgt.org.
doi:10.1093/nar/gku1056 pmid:25378316 pmcid:PMC4383898 fatcat:q5x3oufdlvggrjrpwoqge7tehq