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PriA-directed Assembly of a Primosome on D Loop DNA
1999
Journal of Biological Chemistry
Escherichia coli strains carrying null mutations in priA are chronically induced for the SOS response and are defective in homologous recombination, repair of UV damaged DNA, double-strand break repair, and both induced and constitutive stable DNA replication. This led to the proposal that PriA directed replication fork assembly at D loops formed by the homologous recombination machinery. The demonstration that PriA specifically recognized and bound D loop DNA supported this hypothesis. Using
doi:10.1074/jbc.274.35.25033
pmid:10455182
fatcat:fv63pzplwzbn5njge2imnnsljq