Insulin Response in Relation to Insulin Sensitivity: An Appropriate -Cell Response in Black South African Women: Response to Joffe and Distiller

J. H. Goedecke, E. V. Lambert, N. S. Levitt, T. Olsson, J. R. Seckl, B. R. Walker, S. E. Kahn
2009 Diabetes Care  
W e are in agreement with Joffe and Distiller (1) that the pathogenesis of type 2 diabetes in black South Africans cannot be inferred from limited studies of insulin responses in small cross-sectional studies. In our cross-sectional study, we only examined black and white premenopausal normoglycemic South African women to determine whether there were differences in insulin sensitivity and ␤-cell function in the absence of the potential confounding effects of hyperglycemia. We thus did not
more » ... olate our findings to diabetic individuals, but rather recommended "longitudinal studies to determine whether the ␤-cell will continue to compensate in the black women with increasing age or whether it will fail over time leading to disturbances in glucose tolerance" (2).
doi:10.2337/dc09-1216 fatcat:4t2iniktyfee5k55rhs3ivxfw4