The chemistry of heterocyclic compounds containing five membered 1, 2, 4triazole nucleus has been an intresting field of study for past few decades. The five membered 1, 2, 4-triazole ring exists in two tautomeric forms i.e., 1H-1, 2, 4-triazole, 4H-1, 2, 4-triazole collectively known as s-triazoles. The striazole derivatives possess extensive spectrum of biological activities such as antibacterial, antifungal, antitubercular, anxiolytic, anticonvulsant, antiinflammatory, analgesic, anticancer,

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... antioxidant activities. The present review provides a broad view of pharmacological activity of compounds bearing 1, 2, 4-triazole nucleus. It can be useful for medicinal chemists to design and develop novel compounds consisting 1, 2, 4-triazole nucleus to get better agents in terms of efficacy and safety.