Spectrophotometric Determination of Salbutamol Sulphate by Coupling with Diazotized 5-Amino-2-chlorobenzotrifluoride – Application to Pharmaceutical Preparations

Nabeel S. Othman, Ali M. Asaad
2014 Rafidain journal of science  
A simple, rapid and sensitive spectrophotometic method for the estimation of trace amounts of salbutamol sulphate (SBS) in pharmaceutical preparations has been proposed .The method is based on the coupling reaction of the intended compound with diazotized 5-amino-2chlorobenzotrifluoride in alkaline medium and in the presence of Triton X-100 to form a yelloworange dye that shows maximum absorption at 467 nm. Beer's law is obeyed over the range 5 -300 µg / 10 ml (i.e.,0.5-30 ppm) with a molar
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doi:10.33899/rjs.2014.131346 fatcat:bcf55pnn3ngerj54zcdlwvwkzu