CAR T cell immunotherapy for human cancer

Carl H. June, Roddy S. O'Connor, Omkar U. Kawalekar, Saba Ghassemi, Michael C. Milone
2018 Science  
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with
more » ... a focus on the challenges that have emerged over the past several years.
doi:10.1126/science.aar6711 pmid:29567707 fatcat:hyodm4xtabhurcaeam2mhrfdqm