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CAR T cell immunotherapy for human cancer
2018
Science
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with
doi:10.1126/science.aar6711
pmid:29567707
fatcat:hyodm4xtabhurcaeam2mhrfdqm