Beryllium Content of the Normal Human Prostate Gland: A Systematic Review

Vladimir Zaichick
2021 Acta Scientific Medical Sciences  
The knowledge concerning etiology and pathogenesis of most prostatic malfunction and pathologies is very limited. Notwithstanding advances in medicine, the diagnostics of benign hypertrophic and cancerous prostate has relentlessly increased in intricacy and inconsistency. A supposal has been made that beryllium (Be) level in prostate gland may aid in resolving these problems and especially as a biomarker of prostate cancer. As a result in many studies the normal prostatic Be measurements have
more » ... en made. In present review we analyze data published concerning Be prostatic levels in healthy persons. In total 2161 papers in the literature of the years dating back to 1921 were authenticated in such databases as: PubMed, Scopus, the Cochrane Library, Web of Science and ELSEVIER-EMBASE. Obtained information was subject to an extraction both the Be content ranges and means. In such a way the discrepancy of published Be level of normal glands was estimated. From the articles analyzed, 14 were separated for the impartial evaluation of results from their 645 healthy subjects. Prostatic Be contents (on a wet mass basis) spanned the interval from 0.000155 mg/kg to <0.03 mg/kg with 0.000168 mg/kg as the median of their means. The results covered a wide range of values and the sample was small, hence it is desirable that further investigations with strong quality control of results be performed.
doi:10.31080/asms.2020.05.0872 fatcat:si5277ubcbambb7ig6awuvt74m