e286 13th International Congress on Infectious Diseases Abstracts, Poster Presentations resistance as exemplified by fluconazole and echinocandinsresistant Candida spp. This situation highlights the need for advent of safe, novel and effective antifungal compounds. The objective of this study was to determine whether secondary metabolites produced by a species of Streptomyces was able to exert antifungal effects against seven and five medically important yeast Candida spp. and molds

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... spp. respectively. NCCLS M27A and M38A methods for MIC determination were followed stringently in this screening procedure. Our initial work found all of these fungi were susceptible to the crude fermentative acetone extract (MIC ≤0.625 mg/ml for Candida spp. and ≤2.5 mg/ml for Aspergillus spp.). Five fluconazole-resistant clinical strains were also sensitive to it, with MIC values ≤0.312 mg/ml. In addition, it also totally inhibited C. albicans ATCC 14053 hyphae growth at 0.5 mg/ml. These promising results showed that potential antifungal compounds from secondary metabolites were produced by this species of Streptomyces. This work will be further tested with fractionated extracts and the mechanism of action of potential bioactive compounds will be elucidated.