In India newly diagnosed head and neck cancer constitutes 13.9% of all cancers which is 12.8% of all cancer deaths. Concurrent Chemoradiation is considered the standard of care in locally advanced head and neck carcinomas. Nearly all patients receiving concurrent chemoradiation in the head and neck develop some degree of mucositis. Of these patients treated, some patients develop severe mucositis. Due to this, the patient's quality of life is affected, hospital admission rates are higher, the

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... e of total parenteral nutrition is increased and interruption of treatment is more frequent, all of which compromises tumor control. Severe mucositis causes more treatment interruptions jeopardizing radical treatment outcomes. In the present study, the patients was divided randomly in two groups and all patients received standard fractionation chemoradiation with conventional radiotherapy 64 Gy/32 fractions/6.2 weeks and concomitant injection cisplatin 100 mg/m 2 three week for three cycles. In group I every patient did gargling with Povidone iodine 2%, and in group II every patient did gargling with Benzydamine 0.15%, four times a day, starting from the first day of radiotherapy till fifteenth day after completion of radiotherapy. At the end of treatment, grade III mucositis was observed in 50% patients in group-I while in 13% in group-II. From this study, we conclude that Benzydamine gargling is better than Povidone iodine gargling in decreasing the severity of chemoradiation induced oral mucositis in head and neck cancers.