Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis

Metwaly Khaled, Abdel Sameea Eman, El-Azab Gasser, Assem Medhat, Abbas Mohamed, Zakareya Talaat, Abo Raia Gamal
2016 Journal of Cancer Research and Experimental Oncology  
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The lack of efficient and precise HCC biomarkers prevents early detection resulting in a poor prognosis. Recently, mean platelet volume (MPV) and MPV/platelet count (PC) ratio have been proposed as potential markers of HCC. This study was carried out to verify MPV and MPV/PC ratio in diagnosis of HCC in Egyptian patients with chronic hepatitis C related liver cirrhosis. One hundred and fifty chronic
more » ... C (CHC) patients with chronic hepatitis, cirrhosis or HCC were enrolled in the study. The levels of alphe feto protein (AFP), MPV and MPV/PC ratio were determined compared to 50 healthy persons. MPV and MPV/CP ratio were higher in patients with cirrhosis and those with HCC. The cut off level for MPV for detection of HCC was 10.1 fl, with sensitivity of 70% and specificity of 57%. At a cut off level of 0.82, the sensitivity of MPV/CP ratio was 79.6% and specificity was 72.7%. AFP showed sensitivity 80% and specificity 82% at cut-off level of 16.9 ng/dl. MPV and MPV/PC ratio are less sensitive and specific than AFP as markers for HCC; they may be used only in association with other markers to improve sensitivity of tumor detection.
doi:10.5897/jcreo2016.0135 fatcat:vdsgmoirqrc5zoyexamjqz2rzi