Measles is one of the most interesting of the specific reaction diseases to study, as it has such a definite incubation period and runs such a definite course, not only in its temperature reaction, but also in the manner of the appearance of the eruption. Since making some studies with the measles virus, experimentally reproducing it in monkeys, with E. L. Prizer last year, I have been very much interested in carrying out some of our experimental findings with the idea of using these findings

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... r early diagnosis, especially in reference to isolation, and so preventing the spread of ward epidemics in infants' hospitals. I have had two such opportunities in the wards of the Children's Hospital of the Boston Dispensary: one in June, 1912, and a second in February, 1913. During the first epidemic we had five cases come down with measles and six control cases were followed from the time of first contact. In the second series, there were four cases that came down with measles and four control cases which were open to the same infection and which we were able to study throughout the whole incubation period, but which did not come down with measles; besides in each ease we were able to