Primary hormonal resistance of prostate cancer: clinical and morphological aspects

P. F. Karpov, I. V. Belenky
2020 Onkourologiâ  
By using the routine studies, the authors have analyzed clinical and morphological data of 129 prostate cancer (PC) patients, 48-92 years old with different clinical stages. PC turned out to be initially heterogenic in the composition of tumor cells (cytotypic and immunophenotypic heterogenicity). Therefore combined PC treatment should take into account the presence of hormone-resistant tumor cells even when a neoplasm looks at the light microscopy as a usual low- or moderate-grade
more » ... -grade adenocarcinoma with a great number of adrenoceptors in the tumor cells.
doi:10.17650/1726-9776-2006-2-4-46-49 doaj:ce6f2eb83a8d465ca3f949d882651409 fatcat:xqp2i5thijcsjbg6eldvq6ylnu