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Unique metabolic profiles of Blautia wexlerae achieve beneficial effects for the control of obesity and type 2 diabetes [post]

Koji Hosomi, Mayu Saito, Jonguk Park, Haruka Murakami, Naoko Shibata, Masahiro Ando, Takahiro Nagatake, Kana Konishi, Harumi Ohno, Kumpei Tanisawa, Attayeb Mohsen, Yi-An Chen (+14 others)
2022 unpublished

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The gut microbiome is an important determinant in various diseases. Here we performed a cross-sectional study of Japanese adults and identified the Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration of B. wexlerae to mice induced metabolic changes and anti-inflammatory effects that decreased both high-fat diet–induced obesity and diabetes. The beneficial effects of B. wexlerae were mediated
more » ... irectly by unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and l-ornithine and indirectly by carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate and simultaneous modification of the gut bacterial composition. These findings reveal unique regulatory pathways of host and microbial metabolism that may provide novel strategies in preventive and therapeutic approaches for metabolic disorders.
doi:10.21203/rs.3.rs-1259439/v1 fatcat:mwvginboxzg6jk57ukekjrsny4
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Koji Hosomi, Mayu Saito, Jonguk Park, Haruka Murakami, Naoko Shibata, Masahiro Ando, Takahiro Nagatake, Kana Konishi, Harumi Ohno, Kumpei Tanisawa, Attayeb Mohsen, Yi-An Chen, Hitoshi Kawashima, Yayoi Natsume-Kitatani, Yoshimasa Oka, Hidenori Shimizu, Mari Furuta, Yoko Tojima, Kento Sawane, Azusa Saika, Yasunori Yonejima, Haruko Takeyama, Akira Matsutani, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa. "Unique metabolic profiles of Blautia wexlerae achieve beneficial effects for the control of obesity and type 2 diabetes." (2022)