The Effects of Long-Term Intake of Restricted Calcium, Vitamin D, and Vitamin E and Cadmium-Added Diets on Various Organs and Bones of Mice: A Histological and the Roentgenological Study
マウス諸臓器および骨におよぼすカルシウム,ビタミンD,ビタミンE制限およびカドミウム添加食餌長期摂取の影響:組織学的およびX線的観察

Tsunehiko IMAI, Miyako OMOTO, Kumiko SEKI, Takashi HARADA
1995 Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)  
The toxic effects of long-term administration of cadmium (Cd) on the kidneys, liver, and hind leg bones were studied histologically and roentgenologically in 29-day-old female ICR-strain mice separated into groups variously fed 1) a commercial (caleium [1.17%], vitamin D [220IU/100g], vitamin E [10mg/100g]) diet, 2) a low Ca (0. 18%) diet, 3) a low Ca and low D (50IU/100g) diet, and 4) a low Ca, low D and low E (5mg/ 100g) diet. Though the levels of vitamin D and vitamin E were designed to be
more » ... w in each diet, their amounts fulfilled the nutritional requirements. Theree subgroups in each category were fed Cd at dietary concentrations of 0, 20 or 40ppm. After 12,18 or 24 months on these diets the mice were sacrificed.
doi:10.1265/jjh.50.660 fatcat:vpd4rxlf4zdsfk5khvr26pkkqa