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Emodin inhibits proliferation and invasion, and induces apoptosis in human esophageal cancer cell line ECA109
Tropical Journal of Pharmaceutical Research
Purpose: To determine the anticancer effects of emodin in human esophageal carcinoma cell line ECA109. Methods: Cell viability was determined by MTT assay, while cell invasion and apoptosis were measured by Transwell assay and flow cytometry, respectively. Expression levels of MMP-2, Bax, Bcl-2 and caspase-3 proteins were determined by Western blot. Results: Flow cytometry data showed that the proportion of apoptotic cells was increased by emodin treatment. Apoptotic rates produced by 10, 20doi:10.4314/tjpr.v16i4.6 fatcat:zm3llc62bjczjah4zkc42ktnbi