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Solubilization of the muscarinic acetylcholine receptor by sodium cholate: Stabilization of the receptor by muscarinic ligands
1982
Biomedical research
Preserved Fulltext
Forty to fifty percent of the muscarinic receptor in membrane preparations of porcine caudate nucleus was solubilized by sodium cholate in its active form when the membranes were pretreated with carbamylcholine or other muscarinic ligands. The binding activity of solubilized receptors was assayed by using [3H]quinuclidinylbenzylate ([3H]QNB) after removal of cholate and carbamylcholine. Without the pretreatment, sodium cholate abolished most of the binding activity. The solubilized receptor had
doi:10.2220/biomedres.3.695
fatcat:sd5ncqe4a5hjvpmolxs5pyjdrq