Comprehensive study of a detection mechanism and optimization strategies to improve sensitivity in a nanogap-embedded biotransistor

Sungho Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, Yang-Kyu Choi
2010 Journal of Applied Physics  
A novel biomolecular detection method, charge pumping, is investigated comprehensively as a biosensing mechanism. Tunneling electrons located in channel interface are responsible for a charge pumping current ͑I cp ͒ in a biosensing operation. The maximum tunneling distance ͑d tunnel ͒ of the electrons is the dominant factor to determine the amount of generated I cp , which is closely correlated with the sensitivity in a proposed nanogap-embedded biotransistor structure. Using an analytical
more » ... in which biomolecules are considered as a trap-included insulator, the effects of the key parameters that govern d tunnel , in this case the nanogap height, frequency of the applied pulse, and maximum pulse level, are analyzed.
doi:10.1063/1.3443580 fatcat:elno5yncwfavnkqrhrv5hid4wm