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Hyper-Response of Insulin Release to Arginine in Streptozotocin-Induced Diabetic Rats with Hepatic Vagotomy
Vagal glucose receptor and arginine sensor have been found to exist in the liver of normal rats. The present study was designed to examine whether these sensory receptor systems function in streptozotocin-induced mildly diabetic rats. One week after streptozotocin injection (35 mg/kg body wt. iv), hepatic vagotomy and installation of a jugular vein catheter were performed. Three days after the surgery, intraperitoneal glucose (1 g/kg body wt.) or arginine (1 g/kg body wt.) stimulation was donedoi:10.1507/endocrj1954.37.545 pmid:2083532 fatcat:s3zdaby2cvdfjmerp3g5dpqjuy