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Dyssynchronous Ca2+ Sparks in Myocytes From Infarcted Hearts
2000
Circulation Research
The kinetics of contractions and Ca 2ϩ transients are slowed in myocytes from failing hearts. The mechanisms accounting for these abnormalities remain unclear. Myocardial infarction (MI) was produced by ligation of the circumflex artery in rabbits. We used confocal microscopy to record spatially resolved Ca 2ϩ transients during field stimulation in left ventricular (LV) myocytes from control and infarcted hearts (3 weeks). Compared with controls, Ca 2ϩ transients in myocytes adjacent to the
doi:10.1161/01.res.87.11.1040
pmid:11090550
fatcat:qlik52p65vgmhbgj5mwiioawre