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Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice
2008
Journal of Pharmacological Sciences
The present study was performed to study the participation of histamine H 3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H 3 receptor. Repeated topical application of antigen caused an increase in sneezing and nasal rubbing in sensitized mice. Oral administration of Sch 50971 and imetit, specific H 3 -receptor agonists, resulted in an inhibition of nasal symptoms induced by an antigen similar to an H 1 -receptor antagonist, cetirizine. Furthermore,
doi:10.1254/jphs.08164fp
pmid:18845911
fatcat:eg6grrjmpjcxvml7327fuif46a