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Zebrafish embryo screen identifies anti-metastasis drugs
[article]
2021
bioRxiv
pre-print
Metastasis is responsible for approximately 90% of cancer-associated mortality, but few models exist that allow for rapid and effective screening of anti-metastasis drugs. Here we report a novel screening concept utilizing conserved mechanisms between metastasis and zebrafish gastrulation for identifying anti-metastasis drugs. Molecular mechanisms involved in metastasis and vertebrate gastrulation are conserved; at least fifty common genes play essential roles in governing these mechanisms. We
doi:10.1101/2021.03.04.434001
fatcat:srwhs77pujgelczk7jik4hzdpq