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The c-jun-NH 2 -kinases (JNK) play a critical role in tumor promoter-induced cell transformation and apoptosis. Here, we showed that the nuclear factor of activated T3 (NFAT3) is phosphorylated by JNK1 or JNK2 at Ser 213 and Ser 217 , which are located in the conserved SP motif. The transactivation domain of NFAT3 is found between amino acids (aa) 113 and 260 and includes the phosphorylation targets of JNK1 and JNK2. NFAT3 transactivation activity was suppressed in JNK1 À/À or JNK2 À/À mousedoi:10.1158/0008-5472.can-06-4788 pmid:17875713 fatcat:rxhduvljbreffp6kx3fzqwctn4