Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon?

Rosangela Zacarias Machado, Kayo José Garcia de Almeida Castilho Neto, Luiz Ricardo Gonçalves, Gisele Fabrino Machado, Maria Cecília Rui Luvizotto, Rosemeri de Oliveira Vasconcelos, Giulia Jussiani, Thiago Merighi Vieira da Silva, Lindsay Unno Gimenes, Andrew Jackson, Gavin Wright, Marta Maria Geraldes Teixeira
2021 Revista Brasileira de Parasitologia Veterinária  
Trypanosomiasis, caused by Trypanosoma vivax, is responsible for great economic losses among livestock in Africa and South America. During the life cycle of these parasites, they may present different morphological, metabolic and physiological characteristics depending on the interactions that are encountered at each point of their life cycle. Although T. vivax is frequently reported in the circulation of its mammalian hosts, it has the ability to migrate to the tissues of these individuals.
more » ... ever, this characteristic is poorly understood. In this context, we aimed to investigate the presence of T. vivax and the changes caused in different tissues of experimentally infected goats. Despite the animals were not perfused before tissues collection, using different approaches, we demonstrated its presence in different samples, including in the adipose tissue and skin of infected animals. In addition, a mononuclear inflammatory reaction, mostly characterized by an infiltrate of lymphocytes, plasma cells and macrophages were observed. The results highlight the possibility that, like other trypanosomatids, T. vivax may use these tissues during its life cycle. Future studies aiming to elucidate the length of time for which T. vivax remains active in these sites, and whether it uses these sites as a refuge from trypanocidal drugs, and whether it is capable of recolonizing the blood circulation, are much needed.
doi:10.1590/s1984-29612021092 pmid:34910020 fatcat:qxw3hzcwpngbzmrgskcejwvlaq