A CMOS-based neural implantable optrode for optogenetic stimulation and electrical recording

Hubin Zhao, Fahimeh Dehkhoda, Reza Ramezani, Danil Sokolov, Patrick Degenaar, Yan Liu, Timothy Constandinou
2015 2015 IEEE Biomedical Circuits and Systems Conference (BioCAS)  
This paper presents a novel integrated optrode for simultaneous optical stimulation and electrical recording for closed-loop optogenetic neuro-prosthetic applications. The design has been implemented in a commercially available 0.35µm CMOS process. The system includes circuits for controlling the optical stimulations; recording local field potentials (LFPs); and onboard diagnostics. The neural interface has two clusters of stimulation and recording sites. Each stimulation site has a bonding
more » ... t for connecting a micro light emitting diode (µLED) to deliver light to the targeted area of brain tissue. Each recording site is designed to be post-processed with electrode materials to provide monitoring of neural activity. On-chip diagnostic sensing has been included to provide real-time diagnostics for post-implantation and during normal operation. I.
doi:10.1109/biocas.2015.7348357 dblp:conf/biocas/ZhaoDRSD0C15 fatcat:y5izmxqltzcjtctmwd3hvgz5wi