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Functional Domain Analysis of the Yeast ABC Transporter Ycf1p by Site-directed Mutagenesis
1999
Journal of Biological Chemistry
The yeast cadmium factor (Ycf1p) is a vacuolar protein involved in resistance to Cd 2؉ and to exogenous glutathione S-conjugate precursors in yeast. It belongs to the superfamily of ATP binding cassette transporters, which includes the human cystic fibrosis transmembrane conductance regulator and the multidrug resistance-associated protein. To examine the functional significance of conserved amino acid residues in Ycf1p, we performed an extensive mutational analysis. Twentytwo single amino acid
doi:10.1074/jbc.274.33.23584
pmid:10438540
fatcat:4stausdbg5dpjjip4ysw6u4wfa