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In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery
Oil-in-water nanoemulsions (NEs) represent one of the formulation approaches to improve eye-related bio-availability of lipophilic drugs. The potential of cationic NEs is pronounced due to the electrostatic interaction of positively charged droplets with negatively charged mucins present in the tear film, providing prolonged formulation residence at the ocular surface. The aim of this study was to develop a cationic ophthalmic NE with cationic lipid stearylamine (SA) as a carrier of a positivedoi:10.2478/acph-2019-0054 pmid:31639085 fatcat:his3qlvvjjf5tnnavlte7yblwi