Between the control and the ropivacaine group there were no significant differences in collagen production, breaking-strength measurements, and edema, vascularity, inflammation scores (p > 0.0118). CONCLUSION Surgical wound infiltration has been proven to be an effective analgesic and is widely used for postoperative pain relief after abdominal hysterectomy, cesarean section, inguinal hernia repair, lumbar disc hernia, prostatectomy and similar surgeries. Frequently used local anesthetic agents

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... are lidocaine, bupivacaine, ropivacaine. Research on the effect of these local anesthetic agents used for wound infiltration on wound healing is limited and results are controversia. In our study, we found bupivacaine and lidocaine reduced the collagen production, wound breaking strength, and caused significantly high scores for edema, vascularity, and inflammation when compared to the control group. There was no significant difference between the control and the ropivacaine group. Results of this experimental preliminary study on rats support the idea that ropivacaine can be used for wound infiltration anesthesia without adverse effect on the surgical healing process. These results need to be verified in humans.