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Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways
1998
Journal of Biological Chemistry
The essential cellular functions associated with microtubules have led to a wide use of microtubule-interfering agents in cancer chemotherapy with promising results. Although the most well studied action of microtubule-interfering agents is an arrest of cells at the G 2 /M phase of the cell cycle, other effects may also exist. We have observed that paclitaxel (Taxol), docetaxel ( Taxotere) , vinblastine, vincristine, nocodazole, and colchicine activate the c-Jun N-terminal
doi:10.1074/jbc.273.9.4928
pmid:9478937
fatcat:so5uhjvngjajzdjs5zgh2vitpy