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Lipid Corralling and Poloxamer Squeeze-Out in Membranes
2004
Physical Review Letters
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Using x-ray scattering measurements we have quantitatively determined the effect of poloxamer 188 (P188), a polymer known to seal damaged membranes, on the structure of lipid monolayers. P188 selectively inserts into low lipid-density regions of the membrane and "corrals" lipid molecules to pack tightly, leading to unexpected Bragg peaks at low nominal lipid density and inducing lipid/poloxamer phase separation. At tighter lipid packing, the once inserted P188 is squeezed out, allowing the
doi:10.1103/physrevlett.93.028101
pmid:15323953
fatcat:dnqwfib6pzasjntfsj3smn2mvm