53 mood disorder patients (mean 39±12 years) with 8 or more points on the Hamilton Depression Rating Scale and 58 healthy subjects (mean 36±12 years) were measured RR intervals and accelerations with wearable heart rate sensors (myBeat WHS-1, Union Tool Co., Ltd.) from 15:00 to 3 consecutive days. The average of heart rate variability and activity magnitude during waking and sleeping time period estimated from the accelerations were calculated, and those of patients group were compared with

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... thy subjects group by Mann Whitney U test. Compared with the controls, the patients had shorter RR intervals during both time periods. In the sleep time, the patients had less HF as index of the parasympathetic nervous system than controls. And the patients activity was less than the controls during the waking time periods. It was suggested that heart rate variability and activity magnitude during sleep and waking time periods could be objective indicators of depression.