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Studies on the metabolic fate of (.+-.)-1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylamino-2-propanol hydrochloride (betaxolol hydrochloride) (1): Absorption, distribution, metabolism and excretion after single administration to rats
(±)‐1‐〔4‐〔2‐(Cyclopropylmethoxy)ethyl〕Phenoxy〕‐3‐isopropylamino‐2‐propanol hydrochloride(Betaxolol hydrochloride)の体内動態 (第1報): ラットにおける単回投与時の吸収,分布,代謝および排せつ
1990
Drug Metabolism and Pharmacokinetics
(±)‐1‐〔4‐〔2‐(Cyclopropylmethoxy)ethyl〕Phenoxy〕‐3‐isopropylamino‐2‐propanol hydrochloride(Betaxolol hydrochloride)の体内動態 (第1報): ラットにおける単回投与時の吸収,分布,代謝および排せつ
The absorption, distribution, metabolism and excretion of Betaxolol were investigated in male and female rats after oral or intravenous administration of 14C-Betaxolol . 1. After oral administration of 14C-Betaxolol to male rats , there was a good correlation between the area under time versus concentration curve(AUCt-.-) of radioactivity in blood and administered doses ranging from 0.5 to 5mg/kg. 2. After intravenous administration (1 mg/kg) of 14C-Betaxolol to male rats, blood levels of
doi:10.2133/dmpk.5.675
fatcat:wgsqvgdxifdghcqqryhaqmhng4