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Knockout and expression studies suggest that estrogen receptor ␤ (ER␤) plays a prominent role in ovarian function and pathology. Moreover, ovarian cancers are characterized by high morbidity and low responsiveness to anti-estrogens. Here we demonstrate, using quantitative PCR to measure ER␣ and ER␤ levels in 58 ovarian cancer patients, that ER␤ expression decreased in cysts and ovarian carcinomas as compared with normal ovaries and that this decrease is attributable only to a selective loss indoi:10.1158/0008-5472.can-04-0552 pmid:15313930 fatcat:ywuhodwjwnezxmto3kmxr6iphi