Configuration of the Optic Chiasm in Humans with Albinism as Revealed by Magnetic Resonance Imaging

Bernd Schmitz, Torsten Schaefer, Christoph M. Krick, Wolfgang Reith, Martin Backens, Barbara Ka¨smann-Kellner
2003 Investigative Ophthalmology and Visual Science  
PURPOSE. To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects. METHODS. Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed with observer-independent morphometry and measurements by a blinded observer. RESULTS. The albino group showed significantly smaller chiasmatic widths, smaller optic nerves and
more » ... ts, and wider angles between nerves and tracts. Statistical morphometry showed a different configuration of the optic chiasm. CONCLUSIONS. Size and configuration of the optic chiasm in humans with albinism are distinctly different from those in normal control subjects and reflect the atypical crossing of optic fibers. (Invest Ophthalmol Vis Sci. 2003;44:16 -21)
doi:10.1167/iovs.02-0156 pmid:12506050 fatcat:zthyroyaxzff5bju4i2f5cgwjy