This study aimed to study the causes of bile peritonitis in patients with cholelithiasis treated in 1st clinic of Samar-kand State Medical University. We performed a clinic-based, observational study of patients diagnosed with acute destructive cholecystitis in the 1st Clinic of Samarkand State Medical University. We have observed a significant increase (1.9 times) in the number of operated patients with cholelithiasis in the period 2011-2020 (the number of surgeries was 3801) compared to the

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... cade preceding (table 1) (p<0.01). We studied 131 patients with bile peritonitis, which comprised 2,2% of all operated patients with cholelithiasis. Among them, 82 (7,1%) with peritonitis as a complication of acute destructive cholecystitis, and 49 (0,8%) with peritonitis as a complication after cholelithiasis surgery. Among the patients with peritonitis, there were 39 (29.7%) male and 92 (70.3%) female patients with a gender ratio of 1:2.5. Patients aged 60-69 years old - 41 (31,3%) and 50-59 years old - 37 (28,2%) prevailed. 11 (8.4%) patients were aged 70-79 years, 5 (3.9%) over 80 years, 29 (22.1%) 40-49 years and 8 (6.1%) 30-39 years.