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This study aimed to study the causes of bile peritonitis in patients with cholelithiasis treated in 1st clinic of Samar-kand State Medical University. We performed a clinic-based, observational study of patients diagnosed with acute destructive cholecystitis in the 1st Clinic of Samarkand State Medical University. We have observed a significant increase (1.9 times) in the number of operated patients with cholelithiasis in the period 2011-2020 (the number of surgeries was 3801) compared to thedoi:10.53730/ijhs.v6ns9.13360 fatcat:v5foew6thvgsnbuf6osr25tdcm