Vcfanno: fast, flexible annotation of genetic variants

Brent S. Pedersen, Ryan M. Layer, Aaron R. Quinlan
2016 Genome Biology  
The integration of genome annotations is critical to the identification of genetic variants that are relevant to studies of disease or other traits. However, comprehensive variant annotation with diverse file formats is difficult with existing methods. Here we describe vcfanno, which flexibly extracts and summarizes attributes from multiple annotation files and integrates the annotations within the INFO column of the original VCF file. By leveraging a parallel "chromosome sweeping" algorithm,
more » ... demonstrate substantial performance gains by annotating~85,000 variants per second with 50 attributes from 17 commonly used genome annotation resources. Vcfanno is available at under the MIT license.
doi:10.1186/s13059-016-0973-5 pmid:27250555 pmcid:PMC4888505 fatcat:3dxgarc47zdmhpqrsoksmhleia