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The minimizations of the storage space and transmission time are the two most important riding factors in image compression for telemedicine. Keeping this in view this paper intend to focus on a comparative investigation of three near lossless image compression technique, NLIC (near lossless image compression), SPIHT with DWT (Discrete Wavelets Transform), RLE (Run Length Encoding) with DCT (Discrete Cosine Transform). These techniques are analyzed and tested on various type of square state ofdoi:10.5120/3574-4931 fatcat:k6wd24klgzebddtjcglgyfmchy